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A practical trial that employs various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for pragmatic trials to be able to prove their validity and also helps reduce bias in the results. Too much heterogeneity, however can result in problems with the trial design. Pragmatic Play, one of the major players in the live casino market, provides a variety of classic table games such as Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta offer customers an authentic gambling experience, as well as a broad variety of betting options via virtual. The company has also created several interactive game shows to make gambling online enjoyable. Some of these shows are broadcast live and others are hosted by famous personalities from the industry. 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Its software can be used on mobile devices as well as in various languages. Despite its relative youth, it has already established itself as a premier casino gaming platform. The latest releases include Wolves 5 reel video slot with a healthful RTP and impressive graphics. The other notable titles include Wolf Gold and Chilli Heat. Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. They are usually ordered by policymakers and practitioners to guide their decisions. They also provide a useful method to determine the cause-effect relationship between the intervention and its effects. However, they should not be used in lieu for the use of explanation trials. The idea of pragmatism is controversial, and there are questions about whether pragmatic trials can replace explanatory tests or if they are a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate a physiological or clinical hypothesis and pragmatic trials, which inform policy and practice decisions. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool was designed to define the features of a pragmatic trial which includes the recruitment process, the design and delivery of the intervention, and monitoring. The number of pragmatic trials is increasing. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to note that the majority of these studies were conducted in primary care settings.